Paradoxical High-Level Spiramycin Resistance and Erythromycin Susceptibility due to 23S rRNA Mutation in Streptococcus constellatus
نویسندگان
چکیده
منابع مشابه
detection of mutation in 23s rrna in isolates of streptococcus pyogenes resistant to erythromycin
background: in this study, erythromycin resistance isolates from the students with aged 12-15 yr old were studied and the mutations in the 23s rrna were identified by sequencing. methods: throat samples of 327 students with 12-15 years old from 3 schools of tehran were cultured on the selective streptococcus pyogenes medium and 23 strains were primarily selected as s. pyogenes . results: all ...
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because we included samples from children hospitalized with or without respiratory disease. BLAST search (www.ncbi.nlm. nih.gov/blast/Blast.cgi) and phylogenetic analysis of amplicons from PCR and nested PCR indicated that samples were positive for HKU1 genotype B (samples BRA169, BRA90, and BRA99) or HKU1 genotype A (samples BRA09, BRA37, and BRA104). The sequences obtained in this study have ...
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Host protection from infection relies on the recognition of pathogens by innate pattern-recognition receptors such as Toll-like receptors (TLRs). Here, we show that the orphan receptor TLR13 in mice recognizes a conserved 23S ribosomal RNA (rRNA) sequence that is the binding site of macrolide, lincosamide, and streptogramin group (MLS) antibiotics (including erythromycin) in bacteria. Notably, ...
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ژورنال
عنوان ژورنال: Microbial Drug Resistance
سال: 2020
ISSN: 1076-6294,1931-8448
DOI: 10.1089/mdr.2019.0288